Environmental Enrichment and Ketamine

Ketamine is a rapid-acting antidepressant associated with various cognitive side effects. To mitigate these side
effects while enhancing efficacy, it can be co-administered with other antidepressants. In this study, we adopted a
similar strategy by combining ketamine with environmental enrichment, a potent sensory-motor paradigm, in
adult rats, and observed that combining environmental enrichment with ketamine led to a synergistic antidepressant effect! 

Click to read this result as well as how enrichment altered neuronal activity levels in the habenula following MWM.