Ketamine ointment as a transdermal antidepressant

We developed a novel, shea butter-based ketamine ointment, and showed that transdermal ketamine ameliorated behavioral despair without altering general locomotor activity and anxiety-like behavior. Combining behavioral assessment with pharmacokinetic analysis, we suggest that skin-friendly drug carriers like shea butter may constitute promising alternatives to current routes of delivery for ketamine. 

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